To enable VSync:
-----------------
Within WillowEngine.ini:
Search for "UseVsync" and you should come across the following line:

UseVsync=False

Change to TRUE.

To disable mouse smoothing:
----------------------------
Within WillowInput.ini:
Search for "bEnableMouseSmoothing" and you should come across the following line:

bEnableMouseSmoothing=True

Change to FALSE. This tremendously improves the feel of the mouse when looking around in-game and navigating the UI.

To disable the startup movies:
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Within WillowEngine.ini:

Find:
[FullScreenMovie]
StartupMovies=2K_logo
StartupMovies=Gearbox_logo
StartupMovies=NVidia
StartupMovies=Loading
SkippableMovies=2K_logo
SkippableMovies=Gearbox_logo
SkippableMovies=Attract
SkippableMovies=NVidia

and comment out lines like so:

[FullScreenMovie]
//StartupMovies=2K_logo
//StartupMovies=Gearbox_logo
//StartupMovies=NVidia
//StartupMovies=Loading
//SkippableMovies=2K_logo
//SkippableMovies=Gearbox_logo
//SkippableMovies=Attract
//SkippableMovies=NVidia

If that doesn't work, replace the // with ;